NII, New Delhi
Bioinformatics and Computational Biology Centre,
Over the years, the centre engaged in diversified research areas, spanning systems biology, chemical biology, structural biology, machine learning, and other disciplines. Equipped with state-of-the-art computing resources, the bioinformatics centre supports advanced research projects and has granted over 15 PhD degrees to accomplished scholars.
1. Advanced research in structural bioinformatics for development of multi-scale modelling tools for: In silico identification of microbiome associated metabolites and biochemical pathways affecting cellular processes in host.Genome scale prediction of signaling (Protein-Protein) & regulatory (Protein-RNA/DNA)networks & Analysis of disease associated mutations in coding and non-coding regions
2. Collaborative research programs with experimental research groups in India working on major disease biology projects like malaria, tuberculosis and cancer for facilitating data driven research.
3. Initiating consortium projects involving structural bioinformatics research groups in India in collaboration with leading international bioinformatics centers to build major resources.
4. High end infrastructure building for providing hardware/software resources for MD simulations, drug design and NGS data analysis.5. Manpower development in bioinformatics and computational biology by long/short term training and advanced work."
The centre excels in Bioinformatics/Computational Biology, developing 15+ databases/servers and publishing 75+ impactful papers in esteemed journals. It pioneers computational methods for protein substrate prediction and identifies key biosynthetic pathways. Our recent ML approach to predict modulators of protein-protein interactions, phosphorylation sites and small-ORFs has been published in reputed journals
The centre has a robust computational infrastructure, encompassing high-performance computing (HPC) systems with A100 and V100 GPUs, enabling cutting-edge bioinformatics research. We have also developed numerous tools, web servers, and databases listed at http://202.54.249.134/BIC-NII/databases-servers/, empowering advanced analysis, structural predictions, and genomic exploration in the field.
The centre uses cutting-edge state-of-the-art AI/ML/DL and LLM in the areas of genomics, structural biology and immunology.
The NNP is focused on the discovery of novel drug targets for drug-resistant Mycobacterium tuberculosis using a multi-disciplinary approach in collaboration with leading experimental research groups working on tuberculosis and other researchers with expertise in structural biology and pathway modelling
