The mission of the Centre<\/strong> : <\/strong><\/p>\n 1. To create expertise and trained manpower in Big Data Biology, AI\/ML<\/p>\n 2. To engage in cutting-edge research in clinical genomics and to translate the outcomes into innovative products<\/p>\n 3. To emerge as a leading centre in big data applications in health care and genomics<\/p>\n\t To be a global Centre of Excellence in Viral Bioinformatics To carry out cutting-edge research on viruses infecting all forms of life To employ data-driven, integrative approaches for knowledge discovery and translational research To undertake research projects in the areas of genomics, comparative genomics, metagenomics, immunoinformatics, phyloinformatics, chemo-informatics and bioinformatics To develop curated databases, novel algorithms, servers and specialised resces for viruses To develop computational infrastructure (hardware, software, customisable workflows etc.) for: Genomics & metagenomics Population genetics & evolutionary biology Comparative genomics & systems biology Immunoinformatics & vaccine design Drug repurposing, drug design and deciphering drug resistance To train human resce in the specialised area of viral bioinformatics<\/p>\n\t Seminal contributions include the study of unfolding the mystery of emergence of SARS-Cov-2 through a likely spillover event, to map circulation of SARS-Cov-2 lineages in India, to decode likely impact of virus and host variations on efficacy of vaccine, (sponsored SII, Pune).<\/p>\n The bioinformatics studies of human and animal viruses have an impact on understanding of genetic variability and its consequences on disease gradation, molecular mechanisms of host-virus interactions, diagnostic and therapeutic strategies for viral diseases such as HPV-16 associated cervical cancer, COVID-19, AIDS, measles, Infectious Bovine Rhinotracheitis, Monkeypox, etc.<\/p>\n The Centre maintains state-of-art computational infrastructure.\u00a0 A number of algorithms, databases and web servers have been developed in-house. The Return Time Distribution (RTD) based, alignment-free algorithm for virus typing and subtyping, achieves high accuracy and efficiency in viral typing. ML based algorithm has been developed to predict the antibody class\/es for epitopes.<\/p>\n Basic and applied research on Viral Bioinformatics; Studies of viruses, viral diseases involving phyloinformatics, genomics, immunoinformatics, drug re-purposing, molecular docking and simulations; Development of bioinformatics resces; High-impact publications<\/p>\n\n","protected":false},"excerpt":{"rendered":" Institute of Bioinformatics and Applied Biotechnology (IBAB), Bangalore Centre for Disease Genomics, Bioinformatics and Big Data Analysis in Biology and […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}}},"_links":{"self":[{"href":"https:\/\/apexbtic.icgeb.res.in\/btisnet\/wp-json\/wp\/v2\/pages\/2040"}],"collection":[{"href":"https:\/\/apexbtic.icgeb.res.in\/btisnet\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/apexbtic.icgeb.res.in\/btisnet\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/apexbtic.icgeb.res.in\/btisnet\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/apexbtic.icgeb.res.in\/btisnet\/wp-json\/wp\/v2\/comments?post=2040"}],"version-history":[{"count":2,"href":"https:\/\/apexbtic.icgeb.res.in\/btisnet\/wp-json\/wp\/v2\/pages\/2040\/revisions"}],"predecessor-version":[{"id":3024,"href":"https:\/\/apexbtic.icgeb.res.in\/btisnet\/wp-json\/wp\/v2\/pages\/2040\/revisions\/3024"}],"wp:attachment":[{"href":"https:\/\/apexbtic.icgeb.res.in\/btisnet\/wp-json\/wp\/v2\/media?parent=2040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}