Brief History of the Centre:-
Brief description of the present activities in the area of Bioinformatics and related areas: Molecular evolution 1. Genome composition in microbes: AT skew and GC skew analysis in the context of Chargaff s second parity in bacterial chromosomes (Powdel et al 2009; 2010) 2. Codon usage bias: measurement of synonymous codon usage in microbes and factors influencing usage of optimal codons (Satapathy et al 2012, 2014a, 2014b, 2016, 2017) 3. Mutation analysis: mutation spectra analysis in bacterial genomes by big data analysis 4. Exploring DNA functions using structural properties (Kumar & Bansal 2012; Bansal et al, 2014; Kumar et al, 2016; Kumar and Bansal 2017; Yella et al 2018) DNA structural properties based promoter annotation and gene expression analysis Protein-ligand and protein-protein interaction o Structure prediction of HopS2 5. In silico study on the structure and dynamics of human lemur tyrosine kinase 3 (LMTK3): A new Potential target for breast cancer 6. In silico study on the structural dynamics of amyloid-? peptide (A?1-42), its aggregation pathway and inhibition: to control the geriatric epidemic, Alzheimer s disease. (Dutta & Mattaparthi 2017, 2018) 7. Some Investigations on the causes and inhibition methods of aggregation of Synuclein protein in Parkinson s disease: An in silico approach.(Sanjeev &Mattaparthi, 2019) 8. Computational Insights on the central role of xerodermapigmentosum A (XPA) Protein in Nucleotide Excision Repair (NER); its Polymorphisms and Implications in the Elevations of Cancer (Pradhan & Mattaparthi 2018; Pradhan et al 2019) Quantum mechanical calculation on nucleic acids and proteins 9. Reactivity of DNA bases (Sarmah & Deka 2008) o QM calculation on drug-DNA interactions 10. QASR studies on several anti-cancer, anti-tuberculosis and anti-malarial drug molecules Molecular simulations 11. Docking of drug molecules in protein and nucleic acids o Molecular dynamics simulations on diffusion of drug molecules in proteins o MD simulation for control release of drug molecules (Saikia et al, 2013) Big data analytics in bioinformatics 12. Gene co-expression network analysis in support of disease diagnosis(Mandal et al, 2019; Chowdhury et al, 2019) 13. Machine learning big data analysis (Kashyap et al, 2016) 5 Evolutionary systems biology 14. Next Generation Sequencing and Cancer Genomics o Stress interactions in plants (Barah et al, 2013, 2016) 15. Role of non-coding mutations in genome evolution

Approved Objectives of the Centre:-
1. Workshop
2. Training
3. Teaching
4. Internship
5. Microbial Biodiversity: The study will be mainly targeted to understand microbial biodiversity in Assam and Arunachal Pradesh
6. Molecular evolution
7. Molecular dynamics and Monte Carlo simulations
8. Quantum chemical calculations
9. QM/MM studies on drug DNA, drug RNA and drug protein interactions
10. gene expression analysis using machine learning approach
11. Analysis of DNA structural features

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• Full Name:  Dr. Suvendra Kumar Ray
• Tel:   03712275406
• Email:   suven@tezu.ernet.in
• Location:  Department of Molecular Biology and Biotechnology, Tezpur University, Napaam, Sonitpur, Assam-784 028
• Website:   https://www.tezu.ernet.in/